June 12, 2025 – A Scary Muscle Cramp I Won’t Soon Forget

Last night was awful.

What started as what I thought was a regular leg cramp turned into something much worse. It hit my upper leg—maybe the hamstring, maybe the sartorius muscle—and it locked so violently that I genuinely thought I’d torn something. The pain was so deep, so intense, I couldn’t move. It felt like my leg was broken.

It lasted a full 10 minutes.

I stood there gripping the kitchen counter, breathing through clenched teeth, just waiting for it to stop. When it finally did, I was left exhausted, shaky, and honestly… a little scared.

Could It Be a Vitamin Deficiency?

After 146 weeks on tirzepatide (I start week 147 tomorrow), plus a lower-carb, protein-forward diet, reactive hypoglycemia, and ongoing stress—it’s no wonder my nutrient levels are changing. I did what I always do after something weird happens: I went into research mode.

What kept coming up over and over? Vitamin B1 (thiamine)—and specifically, how a deficiency in B1 can cause extreme muscle cramps, nerve misfires, and even symptoms that mimic injuries.

Why Vitamin B1 Is So Important

Thiamine is critical for:

  • Regulating muscle contraction and nerve signaling

  • Supporting glucose metabolism, especially during low blood sugar events

  • Producing cellular energy (ATP) so your muscles can actually relax after contracting

Without enough thiamine, your nerves miscommunicate with your muscles. You don’t get smooth movement—you get cramps. And if you’re already pushing your body with dietary changes, blood sugar swings, or medications like GLP-1s, your need for B vitamins skyrockets.

What I’m Taking Now: Triquetra BioActive Vitamin B-Complex

Starting today, I’m adding Triquetra’s BioActive B-Complex to my supplement stack. This isn’t just thiamine—it includes the full spectrum of B vitamins, in their methylated and bioavailable forms, including:

  • B1 (Thiamine)

  • B2 (Riboflavin)

  • B3 (Niacin)

  • B6 (Pyridoxal-5-Phosphate)

  • B9 (Folate)

  • B12 (Methylcobalamin)

  • And more…

I chose this particular B-complex because I already trust Triquetra's formulation quality. And for someone like me—on tirzepatide, dealing with reactive hypoglycemia, working long hours on my feet—supporting energy, nerve function, and muscle control isn’t optional. It’s essential.

What I’m Hoping This Helps With

  • Preventing more terrifying leg cramps

  • Supporting my nervous system and blood sugar regulation

  • Boosting energy production and mood

That cramp last night wasn’t just a nuisance. It was a warning. And now I’m taking action.

If you’re on a GLP-1, managing blood sugar swings, or experiencing odd muscle cramps—don’t underestimate the role of B vitamins. Especially B1. Triquetra’s B-Complex makes it simple to cover your bases, and I’ll be tracking how I feel in the coming days.

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