Science Doesn’t Care About Your Snide Comments

Every time someone trots out the tired line “don’t tell me how to lose weight, it’s just calories in, calories out” they reveal how little they’ve kept up with the last decade of actual science. That phrase might sound tough, but it’s outdated and lazy. It ignores the mountain of clinical trials that have already proven obesity is a chronic, relapsing disease with complex hormonal, metabolic, and neurobiological roots. Pretending it’s simply about willpower is like telling a cancer patient to “just stop growing tumors.”

GLP-1 and GIP/GLP-1 medications are not a fad, not a shortcut, and not “cheating.” They are evidence-based therapies with outcomes measured in reduced cardiovascular events, better kidney health, improved sleep apnea, and sustainable fat loss. Trials like SURMOUNT, SURPASS, SELECT, FLOW, and more have changed the entire medical landscape. The data are so compelling that these studies are published in The New England Journal of Medicine and Nature Medicine, not on wellness blogs.

So if you still want to cling to 1980s diet dogma, that’s your choice. But don’t confuse your opinion with scientific fact.

What the Trials Actually Show

  • Tirzepatide (SURMOUNT-1, -3, -4) delivered average weight losses of 20% or more, sustained beyond 72 weeks, and showed that when treatment stops, weight often returns—proof that this is medical management, not a temporary trick.

  • Semaglutide (SELECT, STEP, FLOW) not only reduced body weight but cut the risk of heart attacks and strokes by 20% in people without diabetes. That’s medicine changing lives at the population level.

  • SURMOUNT-OSA showed meaningful reductions in obstructive sleep apnea, proving this goes beyond vanity—it literally improves oxygenation and sleep quality.

  • SYNERGY-NASH and ESSENCE demonstrated reversal of fatty liver disease and fibrosis, conditions that silently destroy livers until it’s too late.

  • OASIS and other oral programs proved these therapies can be effective even without injections.

Closing Thoughts

Yes, the truth is biting. But here’s the other truth: we all deserve better health. If you’ve believed the old “eat less, move more” line, you’re not alone—most of us grew up hearing it. The beauty of science is that when evidence improves, we can improve too. These medicines aren’t about shame, shortcuts, or ego. They’re about reclaiming life, health, and vitality—for ourselves, for our children, and for the clients and patients who trust us.

Mocking progress doesn’t make you strong. Learning, adapting, and evolving does.


References (5 key links)

  1. NEJM – SURMOUNT-1: Tirzepatide Once Weekly for the Treatment of Obesity

  2. NEJM – SELECT: Semaglutide and Cardiovascular Outcomes in Obesity Without Diabetes

  3. Nature Medicine – SURMOUNT-3: Tirzepatide After Lifestyle Intervention

  4. NEJM – FLOW: Semaglutide and Kidney Outcomes in Type 2 Diabetes

  5. NEJM – SURMOUNT-OSA: Tirzepatide in Obstructive Sleep Apnea

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